Compile Data Set for Download or QSAR

Found 51 hits from University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041086 (CHEMBL3355430) Show SMILES OC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@]3([C@H]2c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc32)cc1 |r| Show InChI InChI=1S/C30H26Cl2FN3O4/c31-17-9-12-20-22(15-17)35-28(40)30(20)23(19-5-4-6-21(32)24(19)33)25(36-29(30)13-2-1-3-14-29)26(37)34-18-10-7-16(8-11-18)27(38)39/h4-12,15,23,25,36H,1-3,13-14H2,(H,34,37)(H,35,40)(H,38,39)/t23-,25+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	0.160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50433561 (CHEMBL2381408) Show SMILES CC(C)(C)C[C@@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:8.8,5.4,31.34,wD:17.29,7.31,34.38,(40.88,-57.18,;39.34,-57.18,;38.57,-58.51,;40.11,-58.5,;38.57,-55.84,;37.04,-55.84,;37.52,-54.37,;36.27,-53.47,;35.03,-54.37,;33.51,-54.09,;32.52,-55.27,;31.01,-54.99,;30.49,-53.53,;31.49,-52.36,;30.98,-50.9,;33,-52.64,;34.01,-51.48,;35.49,-55.84,;36.38,-57.1,;37.93,-57.11,;35.48,-58.34,;34.01,-57.86,;32.69,-58.61,;31.36,-57.84,;30.03,-58.6,;31.37,-56.3,;32.71,-55.54,;34.03,-56.32,;36.26,-51.93,;34.93,-51.16,;37.6,-51.15,;37.6,-49.61,;36.26,-48.86,;36.26,-47.31,;37.6,-46.54,;37.6,-45,;38.93,-47.32,;38.93,-48.85,)| Show InChI InChI=1S/C29H34Cl2FN3O3/c1-28(2,3)14-22-29(19-12-7-15(30)13-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-16-8-10-17(36)11-9-16/h4-7,12-13,16-17,22-23,25,35-36H,8-11,14H2,1-3H3,(H,33,37)(H,34,38)/t16-,17-,22-,23-,25+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	0.880	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin)				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041085 (CHEMBL3355429) Show SMILES C[C@@]1(O)C[C@@H](C1)NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:17.30,18.21,4.6,1.1,wD:9.9,(50,-16.12,;48.92,-17.21,;48.14,-15.87,;47.59,-17.99,;48.36,-19.31,;49.69,-18.54,;47.97,-20.8,;46.49,-21.21,;45.39,-20.13,;46.09,-22.71,;47.6,-23.03,;47.75,-24.55,;48.52,-25.88,;50.04,-25.89,;50.82,-24.57,;50.05,-23.24,;48.52,-23.23,;46.36,-25.19,;45.32,-24.04,;44.22,-22.94,;44.63,-21.44,;43.53,-20.34,;42.03,-20.75,;41.63,-22.26,;40.14,-22.66,;42.73,-23.35,;42.34,-24.84,;47.27,-26.44,;48.81,-26.44,;46.37,-27.7,;44.89,-27.23,;43.55,-28,;42.21,-27.23,;40.88,-28,;42.21,-25.69,;43.54,-24.92,;44.88,-25.68,)| Show InChI InChI=1S/C28H30Cl2FN3O3/c1-26(37)13-16(14-26)32-24(35)23-21(17-6-5-7-19(30)22(17)31)28(27(34-23)10-3-2-4-11-27)18-9-8-15(29)12-20(18)33-25(28)36/h5-9,12,16,21,23,34,37H,2-4,10-11,13-14H2,1H3,(H,32,35)(H,33,36)/t16-,21-,23+,26+,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112748 (US8629141, 15) Show SMILES Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCCCC2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1 |r| Show InChI InChI=1S/C29H33Cl2FN4O3/c30-18-7-8-20-22(17-18)34-27(38)29(20)23(19-5-4-6-21(31)24(19)32)25(35-28(29)9-2-1-3-10-28)26(37)33-11-12-36-13-15-39-16-14-36/h4-8,17,23,25,35H,1-3,9-16H2,(H,33,37)(H,34,38)/t23-,25+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041075 (CHEMBL3355417) Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1NC2(CCCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:19.32,20.23,4.7,wD:10.10,1.0,(20.39,-39.2,;20,-40.68,;18.51,-41.08,;18.12,-42.56,;19.21,-43.64,;20.69,-43.24,;21.08,-41.76,;18.82,-45.12,;17.34,-45.52,;16.25,-44.44,;16.95,-47.02,;18.45,-47.33,;18.61,-48.85,;19,-47.37,;20.42,-46.74,;21.79,-47.44,;22.08,-48.96,;21.08,-50.14,;19.54,-50.09,;17.21,-49.48,;16.18,-48.34,;15.09,-47.25,;15.49,-45.75,;14.4,-44.66,;12.9,-45.06,;12.5,-46.57,;11.02,-46.97,;13.6,-47.65,;13.21,-49.14,;18.12,-50.73,;19.65,-50.73,;17.22,-51.99,;15.75,-51.52,;14.41,-52.29,;13.08,-51.52,;11.75,-52.29,;13.09,-49.98,;14.41,-49.22,;15.74,-49.98,)| Show InChI InChI=1S/C30H34Cl2FN3O3/c31-17-8-13-21-23(16-17)35-28(39)30(21)24(20-6-5-7-22(32)25(20)33)26(36-29(30)14-3-1-2-4-15-29)27(38)34-18-9-11-19(37)12-10-18/h5-8,13,16,18-19,24,26,36-37H,1-4,9-12,14-15H2,(H,34,38)(H,35,39)/t18-,19-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041074 (CHEMBL3355416) Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:18.31,19.22,4.7,wD:10.10,1.0,(9.07,-38.56,;8.68,-40.05,;7.19,-40.45,;6.79,-41.95,;7.89,-43.02,;9.37,-42.62,;9.77,-41.14,;7.5,-44.51,;6.01,-44.92,;4.92,-43.83,;5.62,-46.41,;7.12,-46.73,;7.28,-48.26,;8.04,-49.59,;9.56,-49.59,;10.34,-48.27,;9.57,-46.94,;8.04,-46.93,;5.88,-48.89,;4.85,-47.75,;3.75,-46.65,;4.15,-45.15,;3.06,-44.05,;1.55,-44.45,;1.15,-45.96,;-.34,-46.37,;2.26,-47.06,;1.86,-48.54,;6.79,-50.15,;8.33,-50.14,;5.89,-51.41,;4.41,-50.94,;3.07,-51.71,;1.74,-50.94,;.4,-51.71,;1.74,-49.39,;3.07,-48.62,;4.4,-49.39,)| Show InChI InChI=1S/C29H32Cl2FN3O3/c30-16-7-12-20-22(15-16)34-27(38)29(20)23(19-5-4-6-21(31)24(19)32)25(35-28(29)13-2-1-3-14-28)26(37)33-17-8-10-18(36)11-9-17/h4-7,12,15,17-18,23,25,35-36H,1-3,8-11,13-14H2,(H,33,37)(H,34,38)/t17-,18-,23-,25+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041081 (CHEMBL3355425) Show SMILES OC[C@@H](O)CCNC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C27H30Cl2FN3O4/c28-15-7-8-18-20(13-15)32-25(37)27(18)21(17-5-4-6-19(29)22(17)30)23(24(36)31-12-9-16(35)14-34)33-26(27)10-2-1-3-11-26/h4-8,13,16,21,23,33-35H,1-3,9-12,14H2,(H,31,36)(H,32,37)/t16-,21-,23+,27+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041031 (CHEMBL3355411) Show SMILES CCC1(CC)N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:16.18,7.7,30.33,wD:6.30,33.37,(24,-36.43,;23.99,-34.9,;22.65,-34.13,;23.98,-33.36,;23.97,-31.82,;22.5,-32.61,;20.99,-32.29,;20.22,-33.62,;19.12,-32.52,;19.53,-31.02,;18.43,-29.92,;16.93,-30.33,;16.53,-31.84,;15.04,-32.24,;17.63,-32.93,;17.24,-34.42,;21.25,-34.76,;22.17,-36.02,;23.71,-36.02,;21.26,-37.28,;19.79,-36.81,;18.45,-37.58,;17.11,-36.81,;15.78,-37.58,;17.11,-35.27,;18.44,-34.5,;19.78,-35.26,;21.38,-30.79,;20.29,-29.71,;22.87,-30.38,;23.26,-28.9,;22.16,-27.82,;22.56,-26.33,;24.05,-25.93,;24.45,-24.44,;25.14,-27.02,;24.75,-28.5,)| Show InChI InChI=1S/C28H32Cl2FN3O3/c1-3-27(4-2)28(19-13-8-15(29)14-21(19)33-26(28)37)22(18-6-5-7-20(30)23(18)31)24(34-27)25(36)32-16-9-11-17(35)12-10-16/h5-8,13-14,16-17,22,24,34-35H,3-4,9-12H2,1-2H3,(H,32,36)(H,33,37)/t16-,17-,22-,24+,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041073 (CHEMBL3355415) Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1NC2(CCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:17.30,18.21,4.7,wD:10.10,1.0,(66.68,-24.88,;66.28,-26.36,;64.79,-26.77,;64.39,-28.26,;65.49,-29.33,;66.98,-28.94,;67.37,-27.45,;65.1,-30.82,;63.61,-31.23,;62.52,-30.14,;63.22,-32.73,;64.73,-33.04,;64.89,-34.58,;65.98,-35.67,;67.35,-34.97,;67.11,-33.45,;65.59,-33.21,;63.48,-35.2,;62.45,-34.06,;61.35,-32.96,;61.76,-31.46,;60.66,-30.36,;59.16,-30.76,;58.76,-32.28,;57.27,-32.68,;59.86,-33.37,;59.47,-34.86,;64.4,-36.46,;65.94,-36.45,;63.49,-37.72,;62.02,-37.25,;60.67,-38.02,;59.34,-37.25,;58.01,-38.02,;59.34,-35.71,;60.67,-34.94,;62.01,-35.7,)| Show InChI InChI=1S/C28H30Cl2FN3O3/c29-15-6-11-19-21(14-15)33-26(37)28(19)22(18-4-3-5-20(30)23(18)31)24(34-27(28)12-1-2-13-27)25(36)32-16-7-9-17(35)10-8-16/h3-6,11,14,16-17,22,24,34-35H,1-2,7-10,12-13H2,(H,32,36)(H,33,37)/t16-,17-,22-,24+,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041082 (CHEMBL3355426) Show SMILES CCC1(CC)N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1C[C@@](C)(O)C1 |r,wU:16.18,7.7,30.33,32.37,wD:6.30,(10.13,-26.77,;10.12,-25.23,;8.78,-24.47,;10.11,-23.69,;10.1,-22.15,;8.62,-22.94,;7.12,-22.62,;6.35,-23.96,;5.25,-22.86,;5.66,-21.36,;4.56,-20.26,;3.06,-20.66,;2.66,-22.17,;1.18,-22.58,;3.76,-23.26,;3.37,-24.75,;7.38,-25.1,;8.3,-26.35,;9.83,-26.35,;7.39,-27.61,;5.92,-27.14,;4.58,-27.91,;3.24,-27.14,;1.91,-27.91,;3.25,-25.6,;4.57,-24.83,;5.91,-25.59,;7.51,-21.12,;6.42,-20.04,;9,-20.72,;9.39,-19.23,;8.61,-17.9,;9.94,-17.13,;11.02,-16.03,;9.15,-15.79,;10.71,-18.45,)| Show InChI InChI=1S/C27H30Cl2FN3O3/c1-4-26(5-2)27(17-10-9-14(28)11-19(17)32-24(27)35)20(16-7-6-8-18(29)21(16)30)22(33-26)23(34)31-15-12-25(3,36)13-15/h6-11,15,20,22,33,36H,4-5,12-13H2,1-3H3,(H,31,34)(H,32,35)/t15-,20-,22+,25+,27+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041025 (CHEMBL3355410) Show SMILES CC1(C)N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:14.16,5.5,28.31,wD:4.28,31.35,(10.71,-33.09,;9.38,-33.87,;10.72,-34.63,;9.23,-32.35,;7.72,-32.03,;6.96,-33.36,;5.86,-32.26,;6.26,-30.76,;5.17,-29.67,;3.66,-30.07,;3.27,-31.58,;1.78,-31.98,;4.37,-32.67,;3.97,-34.16,;7.99,-34.5,;8.9,-35.76,;10.44,-35.75,;8,-37.02,;6.52,-36.55,;5.18,-37.32,;3.85,-36.55,;2.52,-37.32,;3.85,-35.01,;5.18,-34.24,;6.51,-35,;8.12,-30.53,;7.03,-29.45,;9.6,-30.13,;9.99,-28.64,;8.9,-27.56,;9.3,-26.07,;10.78,-25.67,;11.18,-24.18,;11.87,-26.76,;11.48,-28.24,)| Show InChI InChI=1S/C26H28Cl2FN3O3/c1-25(2)26(17-11-6-13(27)12-19(17)31-24(26)35)20(16-4-3-5-18(28)21(16)29)22(32-25)23(34)30-14-7-9-15(33)10-8-14/h3-6,11-12,14-15,20,22,32-33H,7-10H2,1-2H3,(H,30,34)(H,31,35)/t14-,15-,20-,22+,26+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041072 (CHEMBL3355414) Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1NC2(CCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:16.29,17.20,4.7,wD:10.10,1.0,(53.34,-24.73,;52.95,-26.21,;51.46,-26.61,;51.06,-28.11,;52.16,-29.18,;53.64,-28.78,;54.04,-27.3,;51.77,-30.67,;50.28,-31.08,;49.19,-29.99,;49.89,-32.57,;51.39,-32.89,;51.55,-34.41,;52.88,-35.18,;53.65,-33.85,;52.32,-33.09,;50.15,-35.05,;49.12,-33.91,;48.02,-32.81,;48.43,-31.31,;47.33,-30.21,;45.82,-30.61,;45.43,-32.12,;43.94,-32.53,;46.53,-33.21,;46.14,-34.7,;51.06,-36.31,;52.6,-36.3,;50.16,-37.57,;48.68,-37.1,;47.34,-37.87,;46.01,-37.1,;44.68,-37.86,;46.01,-35.55,;47.34,-34.78,;48.67,-35.55,)| Show InChI InChI=1S/C27H28Cl2FN3O3/c28-14-5-10-18-20(13-14)32-25(36)27(18)21(17-3-1-4-19(29)22(17)30)23(33-26(27)11-2-12-26)24(35)31-15-6-8-16(34)9-7-15/h1,3-5,10,13,15-16,21,23,33-34H,2,6-9,11-12H2,(H,31,35)(H,32,36)/t15-,16-,21-,23+,27+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112739 (US8629141, 6) Show SMILES CCC1(CC)N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1 |r| Show InChI InChI=1S/C28H33Cl2FN4O3/c1-3-27(4-2)28(19-9-8-17(29)16-21(19)33-26(28)37)22(18-6-5-7-20(30)23(18)31)24(34-27)25(36)32-10-11-35-12-14-38-15-13-35/h5-9,16,22,24,34H,3-4,10-15H2,1-2H3,(H,32,36)(H,33,37)/t22-,24+,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041078 (CHEMBL3355422) Show SMILES CCC1(CC)N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCC[C@H](O)CO |r| Show InChI InChI=1S/C26H30Cl2FN3O4/c1-3-25(4-2)26(17-9-8-14(27)12-19(17)31-24(26)36)20(16-6-5-7-18(28)21(16)29)22(32-25)23(35)30-11-10-15(34)13-33/h5-9,12,15,20,22,32-34H,3-4,10-11,13H2,1-2H3,(H,30,35)(H,31,36)/t15-,20-,22+,26+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50300121 ((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...) Show SMILES CC(C)(C)C[C@H]1N[C@H]([C@H](c2cccc(Cl)c2)[C@@]11C(=O)Nc2cc(Cl)c(F)cc12)C(=O)NCC[C@H](O)CO |r| Show InChI InChI=1S/C27H32Cl2FN3O4/c1-26(2,3)12-21-27(17-10-19(30)18(29)11-20(17)32-25(27)37)22(14-5-4-6-15(28)9-14)23(33-21)24(36)31-8-7-16(35)13-34/h4-6,9-11,16,21-23,33-35H,7-8,12-13H2,1-3H3,(H,31,36)(H,32,37)/t16-,21+,22-,23+,27-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin)				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041084 (CHEMBL3355428) Show SMILES C[C@@]1(O)C[C@@H](C1)NC(=O)[C@@H]1NC2(CCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:15.28,16.19,4.6,1.1,wD:9.9,(36.42,-16.83,;35.33,-17.93,;34.55,-16.59,;34,-18.7,;34.78,-20.03,;36.11,-19.25,;34.39,-21.51,;32.9,-21.92,;31.81,-20.84,;32.51,-23.42,;34.01,-23.74,;34.17,-25.26,;35.26,-26.35,;36.35,-25.26,;35.26,-24.17,;32.77,-25.89,;31.74,-24.75,;30.64,-23.65,;31.05,-22.15,;29.95,-21.05,;28.45,-21.46,;28.05,-22.97,;26.56,-23.37,;29.15,-24.06,;28.76,-25.55,;33.69,-27.15,;35.23,-27.15,;32.78,-28.41,;31.31,-27.94,;29.96,-28.71,;28.63,-27.94,;27.3,-28.71,;28.63,-26.4,;29.96,-25.63,;31.3,-26.39,)| Show InChI InChI=1S/C26H26Cl2FN3O3/c1-24(35)11-14(12-24)30-22(33)21-19(15-4-2-5-17(28)20(15)29)26(25(32-21)8-3-9-25)16-7-6-13(27)10-18(16)31-23(26)34/h2,4-7,10,14,19,21,32,35H,3,8-9,11-12H2,1H3,(H,30,33)(H,31,34)/t14-,19-,21+,24+,26+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	53	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041080 (CHEMBL3355424) Show SMILES OC[C@@H](O)CCNC(=O)[C@@H]1NC2(CCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C25H26Cl2FN3O4/c26-13-5-6-16-18(11-13)30-23(35)25(16)19(15-3-1-4-17(27)20(15)28)21(31-24(25)8-2-9-24)22(34)29-10-7-14(33)12-32/h1,3-6,11,14,19,21,31-33H,2,7-10,12H2,(H,29,34)(H,30,35)/t14-,19-,21+,25+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	67	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041077 (CHEMBL3355420) Show SMILES Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCC2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1 |r| Show InChI InChI=1S/C27H29Cl2FN4O3/c28-16-5-6-18-20(15-16)32-25(36)27(18)21(17-3-1-4-19(29)22(17)30)23(33-26(27)7-2-8-26)24(35)31-9-10-34-11-13-37-14-12-34/h1,3-6,15,21,23,33H,2,7-14H2,(H,31,35)(H,32,36)/t21-,23+,27+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041049 (CHEMBL3355412) Show SMILES CCCC1(CCC)N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:18.20,9.9,32.35,wD:8.32,35.39,(39.26,-36.51,;37.93,-35.74,;37.92,-34.2,;36.58,-33.44,;37.91,-32.66,;37.9,-31.12,;39.23,-30.34,;36.43,-31.91,;34.92,-31.59,;34.15,-32.92,;33.05,-31.83,;33.46,-30.32,;32.36,-29.23,;30.86,-29.63,;30.46,-31.14,;28.98,-31.55,;31.56,-32.23,;31.17,-33.72,;35.19,-34.07,;36.1,-35.32,;37.64,-35.32,;35.2,-36.58,;33.72,-36.11,;32.38,-36.88,;31.04,-36.11,;29.71,-36.88,;31.05,-34.57,;32.37,-33.8,;33.71,-34.56,;35.32,-30.09,;34.22,-29.01,;36.8,-29.69,;37.19,-28.2,;36.1,-27.12,;36.5,-25.63,;37.98,-25.23,;38.38,-23.74,;39.07,-26.32,;38.68,-27.8,)| Show InChI InChI=1S/C30H36Cl2FN3O3/c1-3-14-29(15-4-2)30(21-13-8-17(31)16-23(21)35-28(30)39)24(20-6-5-7-22(32)25(20)33)26(36-29)27(38)34-18-9-11-19(37)12-10-18/h5-8,13,16,18-19,24,26,36-37H,3-4,9-12,14-15H2,1-2H3,(H,34,38)(H,35,39)/t18-,19-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	105	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50069799 (CHEMBL3407579 | US9187441, 7M) Show SMILES CC(C)(C)NC(=O)C(N(Cc1cc(F)c(F)c(F)c1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin)				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041056 (CHEMBL3355413) Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1NC2(CCC2)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:17.20,4.7,wD:16.29,10.10,1.0,(53.34,-24.73,;52.95,-26.21,;51.46,-26.61,;51.06,-28.11,;52.16,-29.18,;53.64,-28.78,;54.04,-27.3,;51.77,-30.67,;50.28,-31.08,;49.19,-29.99,;49.89,-32.57,;51.39,-32.89,;51.55,-34.41,;52.88,-35.18,;53.65,-33.85,;52.32,-33.09,;50.15,-35.05,;49.12,-33.91,;48.02,-32.81,;48.43,-31.31,;47.33,-30.21,;45.82,-30.61,;45.43,-32.12,;43.94,-32.53,;46.53,-33.21,;46.14,-34.7,;51.06,-36.31,;52.6,-36.3,;50.16,-37.57,;48.68,-37.1,;47.34,-37.87,;46.01,-37.1,;44.68,-37.86,;46.01,-35.55,;47.34,-34.78,;48.67,-35.55,)| Show InChI InChI=1S/C27H28Cl2FN3O3/c28-14-5-10-18-20(13-14)32-25(36)27(18)21(17-3-1-4-19(29)22(17)30)23(33-26(27)11-2-12-26)24(35)31-15-6-8-16(34)9-7-15/h1,3-5,10,13,15-16,21,23,33-34H,2,6-9,11-12H2,(H,31,35)(H,32,36)/t15-,16-,21-,23+,27-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	234	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50436047 (CHEMBL1233798) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(Cl)cc1)-c1ccccc1 |(-2.71,1.13,;-1.94,2.47,;-2.71,3.8,;-.4,2.47,;.5,3.71,;1.96,3.24,;3.3,4.01,;4.63,3.24,;5.97,4.01,;4.63,1.7,;3.3,.93,;1.96,1.7,;.5,1.22,;.02,-.24,;.93,-1.49,;.02,-2.73,;-1.44,-2.26,;-1.44,-.72,;-2.69,.19,;-4.09,-.44,;-4.25,-1.97,;-5.66,-2.6,;-6.91,-1.69,;-8.31,-2.32,;-6.75,-.16,;-5.34,.47,;2.47,-1.49,;3.24,-.15,;4.78,-.15,;5.55,-1.49,;4.78,-2.82,;3.24,-2.82,)| Show InChI InChI=1S/C25H17Cl2N3O2/c26-17-8-6-15(7-9-17)13-30-14-28-22(16-4-2-1-3-5-16)24(30)21-19-11-10-18(27)12-20(19)29-23(21)25(31)32/h1-12,14,29H,13H2,(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem	MMDB PDB Article PubMed	916	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human MDM2 by fluorescence polarization assay				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041083 (CHEMBL3355427) Show SMILES C[C@@]1(O)C[C@@H](C1)NC(=O)[C@@H]1NC2(CCC2)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:16.19,4.6,1.1,wD:15.28,9.9,(24.14,-15.76,;23.06,-16.86,;22.28,-15.52,;21.73,-17.64,;22.51,-18.96,;23.84,-18.19,;22.12,-20.45,;20.63,-20.86,;19.54,-19.77,;20.24,-22.35,;21.74,-22.67,;21.9,-24.2,;22.99,-25.29,;24.08,-24.2,;22.99,-23.11,;20.5,-24.83,;19.47,-23.69,;18.37,-22.59,;18.78,-21.09,;17.68,-19.99,;16.17,-20.39,;15.78,-21.9,;14.29,-22.31,;16.88,-22.99,;16.48,-24.48,;21.41,-26.09,;22.95,-26.08,;20.51,-27.35,;19.03,-26.88,;17.69,-27.65,;16.36,-26.88,;15.02,-27.65,;16.36,-25.33,;17.69,-24.56,;19.02,-25.33,)| Show InChI InChI=1S/C26H26Cl2FN3O3/c1-24(35)11-14(12-24)30-22(33)21-19(15-4-2-5-17(28)20(15)29)26(25(32-21)8-3-9-25)16-7-6-13(27)10-18(16)31-23(26)34/h2,4-7,10,14,19,21,32,35H,3,8-9,11-12H2,1H3,(H,30,33)(H,31,34)/t14-,19-,21+,24+,26-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041079 (CHEMBL3355423) Show SMILES OC[C@@H](O)CCNC(=O)[C@@H]1NC2(CCC2)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C25H26Cl2FN3O4/c26-13-5-6-16-18(11-13)30-23(35)25(16)19(15-3-1-4-17(27)20(15)28)21(31-24(25)8-2-9-24)22(34)29-10-7-14(33)12-32/h1,3-6,11,14,19,21,31-33H,2,7-10,12H2,(H,29,34)(H,30,35)/t14-,19-,21+,25-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.24E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041076 (CHEMBL3355419) Show SMILES Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCC2)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1 |r| Show InChI InChI=1S/C27H29Cl2FN4O3/c28-16-5-6-18-20(15-16)32-25(36)27(18)21(17-3-1-4-19(29)22(17)30)23(33-26(27)7-2-8-26)24(35)31-9-10-34-11-13-37-14-12-34/h1,3-6,15,21,23,33H,2,7-14H2,(H,31,35)(H,32,36)/t21-,23+,27-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50069800 (CHEMBL3407578) Show SMILES CC(C)C[C@H]1N[C@H]([C@H](c2ccccc2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N(C)C |r| Show InChI InChI=1S/C24H28ClN3O2/c1-14(2)12-19-24(17-11-10-16(25)13-18(17)26-23(24)30)20(15-8-6-5-7-9-15)21(27-19)22(29)28(3)4/h5-11,13-14,19-21,27H,12H2,1-4H3,(H,26,30)/t19-,20+,21-,24+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.46E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin)				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041086 (CHEMBL3355430) Show SMILES OC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@]3([C@H]2c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc32)cc1 |r| Show InChI InChI=1S/C30H26Cl2FN3O4/c31-17-9-12-20-22(15-17)35-28(40)30(20)23(19-5-4-6-21(32)24(19)33)25(36-29(30)13-2-1-3-14-29)26(37)34-18-10-7-16(8-11-18)27(38)39/h4-12,15,23,25,36H,1-3,13-14H2,(H,34,37)(H,35,40)(H,38,39)/t23-,25+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041075 (CHEMBL3355417) Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1NC2(CCCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:19.32,20.23,4.7,wD:10.10,1.0,(20.39,-39.2,;20,-40.68,;18.51,-41.08,;18.12,-42.56,;19.21,-43.64,;20.69,-43.24,;21.08,-41.76,;18.82,-45.12,;17.34,-45.52,;16.25,-44.44,;16.95,-47.02,;18.45,-47.33,;18.61,-48.85,;19,-47.37,;20.42,-46.74,;21.79,-47.44,;22.08,-48.96,;21.08,-50.14,;19.54,-50.09,;17.21,-49.48,;16.18,-48.34,;15.09,-47.25,;15.49,-45.75,;14.4,-44.66,;12.9,-45.06,;12.5,-46.57,;11.02,-46.97,;13.6,-47.65,;13.21,-49.14,;18.12,-50.73,;19.65,-50.73,;17.22,-51.99,;15.75,-51.52,;14.41,-52.29,;13.08,-51.52,;11.75,-52.29,;13.09,-49.98,;14.41,-49.22,;15.74,-49.98,)| Show InChI InChI=1S/C30H34Cl2FN3O3/c31-17-8-13-21-23(16-17)35-28(39)30(21)24(20-6-5-7-22(32)25(20)33)26(36-29(30)14-3-1-2-4-15-29)27(38)34-18-9-11-19(37)12-10-18/h5-8,13,16,18-19,24,26,36-37H,1-4,9-12,14-15H2,(H,34,38)(H,35,39)/t18-,19-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041074 (CHEMBL3355416) Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:18.31,19.22,4.7,wD:10.10,1.0,(9.07,-38.56,;8.68,-40.05,;7.19,-40.45,;6.79,-41.95,;7.89,-43.02,;9.37,-42.62,;9.77,-41.14,;7.5,-44.51,;6.01,-44.92,;4.92,-43.83,;5.62,-46.41,;7.12,-46.73,;7.28,-48.26,;8.04,-49.59,;9.56,-49.59,;10.34,-48.27,;9.57,-46.94,;8.04,-46.93,;5.88,-48.89,;4.85,-47.75,;3.75,-46.65,;4.15,-45.15,;3.06,-44.05,;1.55,-44.45,;1.15,-45.96,;-.34,-46.37,;2.26,-47.06,;1.86,-48.54,;6.79,-50.15,;8.33,-50.14,;5.89,-51.41,;4.41,-50.94,;3.07,-51.71,;1.74,-50.94,;.4,-51.71,;1.74,-49.39,;3.07,-48.62,;4.4,-49.39,)| Show InChI InChI=1S/C29H32Cl2FN3O3/c30-16-7-12-20-22(15-16)34-27(38)29(20)23(19-5-4-6-21(31)24(19)32)25(35-28(29)13-2-1-3-14-28)26(37)33-17-8-10-18(36)11-9-17/h4-7,12,15,17-18,23,25,35-36H,1-3,8-11,13-14H2,(H,33,37)(H,34,38)/t17-,18-,23-,25+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041085 (CHEMBL3355429) Show SMILES C[C@@]1(O)C[C@@H](C1)NC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:17.30,18.21,4.6,1.1,wD:9.9,(50,-16.12,;48.92,-17.21,;48.14,-15.87,;47.59,-17.99,;48.36,-19.31,;49.69,-18.54,;47.97,-20.8,;46.49,-21.21,;45.39,-20.13,;46.09,-22.71,;47.6,-23.03,;47.75,-24.55,;48.52,-25.88,;50.04,-25.89,;50.82,-24.57,;50.05,-23.24,;48.52,-23.23,;46.36,-25.19,;45.32,-24.04,;44.22,-22.94,;44.63,-21.44,;43.53,-20.34,;42.03,-20.75,;41.63,-22.26,;40.14,-22.66,;42.73,-23.35,;42.34,-24.84,;47.27,-26.44,;48.81,-26.44,;46.37,-27.7,;44.89,-27.23,;43.55,-28,;42.21,-27.23,;40.88,-28,;42.21,-25.69,;43.54,-24.92,;44.88,-25.68,)| Show InChI InChI=1S/C28H30Cl2FN3O3/c1-26(37)13-16(14-26)32-24(35)23-21(17-6-5-7-19(30)22(17)31)28(27(34-23)10-3-2-4-11-27)18-9-8-15(29)12-20(18)33-25(28)36/h5-9,12,16,21,23,34,37H,2-4,10-11,13-14H2,1H3,(H,32,35)(H,33,36)/t16-,21-,23+,26+,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112748 (US8629141, 15) Show SMILES Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCCCC2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1 |r| Show InChI InChI=1S/C29H33Cl2FN4O3/c30-18-7-8-20-22(17-18)34-27(38)29(20)23(19-5-4-6-21(31)24(19)32)25(35-28(29)9-2-1-3-10-28)26(37)33-11-12-36-13-15-39-16-14-36/h4-8,17,23,25,35H,1-3,9-16H2,(H,33,37)(H,34,38)/t23-,25+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041081 (CHEMBL3355425) Show SMILES OC[C@@H](O)CCNC(=O)[C@@H]1NC2(CCCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C27H30Cl2FN3O4/c28-15-7-8-18-20(13-15)32-25(37)27(18)21(17-5-4-6-19(29)22(17)30)23(24(36)31-12-9-16(35)14-34)33-26(27)10-2-1-3-11-26/h4-8,13,16,21,23,33-35H,1-3,9-12,14H2,(H,31,36)(H,32,37)/t16-,21-,23+,27+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041031 (CHEMBL3355411) Show SMILES CCC1(CC)N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:16.18,7.7,30.33,wD:6.30,33.37,(24,-36.43,;23.99,-34.9,;22.65,-34.13,;23.98,-33.36,;23.97,-31.82,;22.5,-32.61,;20.99,-32.29,;20.22,-33.62,;19.12,-32.52,;19.53,-31.02,;18.43,-29.92,;16.93,-30.33,;16.53,-31.84,;15.04,-32.24,;17.63,-32.93,;17.24,-34.42,;21.25,-34.76,;22.17,-36.02,;23.71,-36.02,;21.26,-37.28,;19.79,-36.81,;18.45,-37.58,;17.11,-36.81,;15.78,-37.58,;17.11,-35.27,;18.44,-34.5,;19.78,-35.26,;21.38,-30.79,;20.29,-29.71,;22.87,-30.38,;23.26,-28.9,;22.16,-27.82,;22.56,-26.33,;24.05,-25.93,;24.45,-24.44,;25.14,-27.02,;24.75,-28.5,)| Show InChI InChI=1S/C28H32Cl2FN3O3/c1-3-27(4-2)28(19-13-8-15(29)14-21(19)33-26(28)37)22(18-6-5-7-20(30)23(18)31)24(34-27)25(36)32-16-9-11-17(35)12-10-16/h5-8,13-14,16-17,22,24,34-35H,3-4,9-12H2,1-2H3,(H,32,36)(H,33,37)/t16-,17-,22-,24+,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041073 (CHEMBL3355415) Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1NC2(CCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:17.30,18.21,4.7,wD:10.10,1.0,(66.68,-24.88,;66.28,-26.36,;64.79,-26.77,;64.39,-28.26,;65.49,-29.33,;66.98,-28.94,;67.37,-27.45,;65.1,-30.82,;63.61,-31.23,;62.52,-30.14,;63.22,-32.73,;64.73,-33.04,;64.89,-34.58,;65.98,-35.67,;67.35,-34.97,;67.11,-33.45,;65.59,-33.21,;63.48,-35.2,;62.45,-34.06,;61.35,-32.96,;61.76,-31.46,;60.66,-30.36,;59.16,-30.76,;58.76,-32.28,;57.27,-32.68,;59.86,-33.37,;59.47,-34.86,;64.4,-36.46,;65.94,-36.45,;63.49,-37.72,;62.02,-37.25,;60.67,-38.02,;59.34,-37.25,;58.01,-38.02,;59.34,-35.71,;60.67,-34.94,;62.01,-35.7,)| Show InChI InChI=1S/C28H30Cl2FN3O3/c29-15-6-11-19-21(14-15)33-26(37)28(19)22(18-4-3-5-20(30)23(18)31)24(34-27(28)12-1-2-13-27)25(36)32-16-7-9-17(35)10-8-16/h3-6,11,14,16-17,22,24,34-35H,1-2,7-10,12-13H2,(H,32,36)(H,33,37)/t16-,17-,22-,24+,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50229787 ((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...) Show SMILES COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1 |t:6| Show InChI InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin)				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041082 (CHEMBL3355426) Show SMILES CCC1(CC)N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1C[C@@](C)(O)C1 |r,wU:16.18,7.7,30.33,32.37,wD:6.30,(10.13,-26.77,;10.12,-25.23,;8.78,-24.47,;10.11,-23.69,;10.1,-22.15,;8.62,-22.94,;7.12,-22.62,;6.35,-23.96,;5.25,-22.86,;5.66,-21.36,;4.56,-20.26,;3.06,-20.66,;2.66,-22.17,;1.18,-22.58,;3.76,-23.26,;3.37,-24.75,;7.38,-25.1,;8.3,-26.35,;9.83,-26.35,;7.39,-27.61,;5.92,-27.14,;4.58,-27.91,;3.24,-27.14,;1.91,-27.91,;3.25,-25.6,;4.57,-24.83,;5.91,-25.59,;7.51,-21.12,;6.42,-20.04,;9,-20.72,;9.39,-19.23,;8.61,-17.9,;9.94,-17.13,;11.02,-16.03,;9.15,-15.79,;10.71,-18.45,)| Show InChI InChI=1S/C27H30Cl2FN3O3/c1-4-26(5-2)27(17-10-9-14(28)11-19(17)32-24(27)35)20(16-7-6-8-18(29)21(16)30)22(33-26)23(34)31-15-12-25(3,36)13-15/h6-11,15,20,22,33,36H,4-5,12-13H2,1-3H3,(H,31,34)(H,32,35)/t15-,20-,22+,25+,27+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	118	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50392531 (CHEMBL407632) Show SMILES CCOc1cc(OC)ccc1C1=N[C@H]([C@H](N1C(=O)N1CCN(CCO)CC1)c1ccc(Br)cc1)c1ccc(Br)cc1 |r,t:12| Show InChI InChI=1S/C31H34Br2N4O4/c1-3-41-27-20-25(40-2)12-13-26(27)30-34-28(21-4-8-23(32)9-5-21)29(22-6-10-24(33)11-7-22)37(30)31(39)36-16-14-35(15-17-36)18-19-38/h4-13,20,28-29,38H,3,14-19H2,1-2H3/t28-,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin)				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041072 (CHEMBL3355414) Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1NC2(CCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:16.29,17.20,4.7,wD:10.10,1.0,(53.34,-24.73,;52.95,-26.21,;51.46,-26.61,;51.06,-28.11,;52.16,-29.18,;53.64,-28.78,;54.04,-27.3,;51.77,-30.67,;50.28,-31.08,;49.19,-29.99,;49.89,-32.57,;51.39,-32.89,;51.55,-34.41,;52.88,-35.18,;53.65,-33.85,;52.32,-33.09,;50.15,-35.05,;49.12,-33.91,;48.02,-32.81,;48.43,-31.31,;47.33,-30.21,;45.82,-30.61,;45.43,-32.12,;43.94,-32.53,;46.53,-33.21,;46.14,-34.7,;51.06,-36.31,;52.6,-36.3,;50.16,-37.57,;48.68,-37.1,;47.34,-37.87,;46.01,-37.1,;44.68,-37.86,;46.01,-35.55,;47.34,-34.78,;48.67,-35.55,)| Show InChI InChI=1S/C27H28Cl2FN3O3/c28-14-5-10-18-20(13-14)32-25(36)27(18)21(17-3-1-4-19(29)22(17)30)23(33-26(27)11-2-12-26)24(35)31-15-6-8-16(34)9-7-15/h1,3-5,10,13,15-16,21,23,33-34H,2,6-9,11-12H2,(H,31,35)(H,32,36)/t15-,16-,21-,23+,27+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	149	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041025 (CHEMBL3355410) Show SMILES CC1(C)N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:14.16,5.5,28.31,wD:4.28,31.35,(10.71,-33.09,;9.38,-33.87,;10.72,-34.63,;9.23,-32.35,;7.72,-32.03,;6.96,-33.36,;5.86,-32.26,;6.26,-30.76,;5.17,-29.67,;3.66,-30.07,;3.27,-31.58,;1.78,-31.98,;4.37,-32.67,;3.97,-34.16,;7.99,-34.5,;8.9,-35.76,;10.44,-35.75,;8,-37.02,;6.52,-36.55,;5.18,-37.32,;3.85,-36.55,;2.52,-37.32,;3.85,-35.01,;5.18,-34.24,;6.51,-35,;8.12,-30.53,;7.03,-29.45,;9.6,-30.13,;9.99,-28.64,;8.9,-27.56,;9.3,-26.07,;10.78,-25.67,;11.18,-24.18,;11.87,-26.76,;11.48,-28.24,)| Show InChI InChI=1S/C26H28Cl2FN3O3/c1-25(2)26(17-11-6-13(27)12-19(17)31-24(26)35)20(16-4-3-5-18(28)21(16)29)22(32-25)23(34)30-14-7-9-15(33)10-8-14/h3-6,11-12,14-15,20,22,32-33H,7-10H2,1-2H3,(H,30,34)(H,31,35)/t14-,15-,20-,22+,26+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	151	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM112739 (US8629141, 6) Show SMILES CCC1(CC)N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1 |r| Show InChI InChI=1S/C28H33Cl2FN4O3/c1-3-27(4-2)28(19-9-8-17(29)16-21(19)33-26(28)37)22(18-6-5-7-20(30)23(18)31)24(34-27)25(36)32-10-11-35-12-14-38-15-13-35/h5-9,16,22,24,34H,3-4,10-15H2,1-2H3,(H,32,36)(H,33,37)/t22-,24+,28+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	167	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041078 (CHEMBL3355422) Show SMILES CCC1(CC)N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCC[C@H](O)CO |r| Show InChI InChI=1S/C26H30Cl2FN3O4/c1-3-25(4-2)26(17-9-8-14(27)12-19(17)31-24(26)36)20(16-6-5-7-18(28)21(16)29)22(32-25)23(35)30-11-10-15(34)13-33/h5-9,12,15,20,22,32-34H,3-4,10-11,13H2,1-2H3,(H,30,35)(H,31,36)/t15-,20-,22+,26+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	175	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041084 (CHEMBL3355428) Show SMILES C[C@@]1(O)C[C@@H](C1)NC(=O)[C@@H]1NC2(CCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:15.28,16.19,4.6,1.1,wD:9.9,(36.42,-16.83,;35.33,-17.93,;34.55,-16.59,;34,-18.7,;34.78,-20.03,;36.11,-19.25,;34.39,-21.51,;32.9,-21.92,;31.81,-20.84,;32.51,-23.42,;34.01,-23.74,;34.17,-25.26,;35.26,-26.35,;36.35,-25.26,;35.26,-24.17,;32.77,-25.89,;31.74,-24.75,;30.64,-23.65,;31.05,-22.15,;29.95,-21.05,;28.45,-21.46,;28.05,-22.97,;26.56,-23.37,;29.15,-24.06,;28.76,-25.55,;33.69,-27.15,;35.23,-27.15,;32.78,-28.41,;31.31,-27.94,;29.96,-28.71,;28.63,-27.94,;27.3,-28.71,;28.63,-26.4,;29.96,-25.63,;31.3,-26.39,)| Show InChI InChI=1S/C26H26Cl2FN3O3/c1-24(35)11-14(12-24)30-22(33)21-19(15-4-2-5-17(28)20(15)29)26(25(32-21)8-3-9-25)16-7-6-13(27)10-18(16)31-23(26)34/h2,4-7,10,14,19,21,32,35H,3,8-9,11-12H2,1H3,(H,30,33)(H,31,34)/t14-,19-,21+,24+,26+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	396	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041080 (CHEMBL3355424) Show SMILES OC[C@@H](O)CCNC(=O)[C@@H]1NC2(CCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C25H26Cl2FN3O4/c26-13-5-6-16-18(11-13)30-23(35)25(16)19(15-3-1-4-17(27)20(15)28)21(31-24(25)8-2-9-24)22(34)29-10-7-14(33)12-32/h1,3-6,11,14,19,21,31-33H,2,7-10,12H2,(H,29,34)(H,30,35)/t14-,19-,21+,25+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	494	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041077 (CHEMBL3355420) Show SMILES Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCC2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1 |r| Show InChI InChI=1S/C27H29Cl2FN4O3/c28-16-5-6-18-20(15-16)32-25(36)27(18)21(17-3-1-4-19(29)22(17)30)23(33-26(27)7-2-8-26)24(35)31-9-10-34-11-13-37-14-12-34/h1,3-6,15,21,23,33H,2,7-14H2,(H,31,35)(H,32,36)/t21-,23+,27+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	589	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041049 (CHEMBL3355412) Show SMILES CCCC1(CCC)N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:18.20,9.9,32.35,wD:8.32,35.39,(39.26,-36.51,;37.93,-35.74,;37.92,-34.2,;36.58,-33.44,;37.91,-32.66,;37.9,-31.12,;39.23,-30.34,;36.43,-31.91,;34.92,-31.59,;34.15,-32.92,;33.05,-31.83,;33.46,-30.32,;32.36,-29.23,;30.86,-29.63,;30.46,-31.14,;28.98,-31.55,;31.56,-32.23,;31.17,-33.72,;35.19,-34.07,;36.1,-35.32,;37.64,-35.32,;35.2,-36.58,;33.72,-36.11,;32.38,-36.88,;31.04,-36.11,;29.71,-36.88,;31.05,-34.57,;32.37,-33.8,;33.71,-34.56,;35.32,-30.09,;34.22,-29.01,;36.8,-29.69,;37.19,-28.2,;36.1,-27.12,;36.5,-25.63,;37.98,-25.23,;38.38,-23.74,;39.07,-26.32,;38.68,-27.8,)| Show InChI InChI=1S/C30H36Cl2FN3O3/c1-3-14-29(15-4-2)30(21-13-8-17(31)16-23(21)35-28(30)39)24(20-6-5-7-22(32)25(20)33)26(36-29)27(38)34-18-9-11-19(37)12-10-18/h5-8,13,16,18-19,24,26,36-37H,3-4,9-12,14-15H2,1-2H3,(H,34,38)(H,35,39)/t18-,19-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	775	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041056 (CHEMBL3355413) Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)[C@@H]1NC2(CCC2)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:17.20,4.7,wD:16.29,10.10,1.0,(53.34,-24.73,;52.95,-26.21,;51.46,-26.61,;51.06,-28.11,;52.16,-29.18,;53.64,-28.78,;54.04,-27.3,;51.77,-30.67,;50.28,-31.08,;49.19,-29.99,;49.89,-32.57,;51.39,-32.89,;51.55,-34.41,;52.88,-35.18,;53.65,-33.85,;52.32,-33.09,;50.15,-35.05,;49.12,-33.91,;48.02,-32.81,;48.43,-31.31,;47.33,-30.21,;45.82,-30.61,;45.43,-32.12,;43.94,-32.53,;46.53,-33.21,;46.14,-34.7,;51.06,-36.31,;52.6,-36.3,;50.16,-37.57,;48.68,-37.1,;47.34,-37.87,;46.01,-37.1,;44.68,-37.86,;46.01,-35.55,;47.34,-34.78,;48.67,-35.55,)| Show InChI InChI=1S/C27H28Cl2FN3O3/c28-14-5-10-18-20(13-14)32-25(36)27(18)21(17-3-1-4-19(29)22(17)30)23(33-26(27)11-2-12-26)24(35)31-15-6-8-16(34)9-7-15/h1,3-5,10,13,15-16,21,23,33-34H,2,6-9,11-12H2,(H,31,35)(H,32,36)/t15-,16-,21-,23+,27-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.72E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041083 (CHEMBL3355427) Show SMILES C[C@@]1(O)C[C@@H](C1)NC(=O)[C@@H]1NC2(CCC2)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:16.19,4.6,1.1,wD:15.28,9.9,(24.14,-15.76,;23.06,-16.86,;22.28,-15.52,;21.73,-17.64,;22.51,-18.96,;23.84,-18.19,;22.12,-20.45,;20.63,-20.86,;19.54,-19.77,;20.24,-22.35,;21.74,-22.67,;21.9,-24.2,;22.99,-25.29,;24.08,-24.2,;22.99,-23.11,;20.5,-24.83,;19.47,-23.69,;18.37,-22.59,;18.78,-21.09,;17.68,-19.99,;16.17,-20.39,;15.78,-21.9,;14.29,-22.31,;16.88,-22.99,;16.48,-24.48,;21.41,-26.09,;22.95,-26.08,;20.51,-27.35,;19.03,-26.88,;17.69,-27.65,;16.36,-26.88,;15.02,-27.65,;16.36,-25.33,;17.69,-24.56,;19.02,-25.33,)| Show InChI InChI=1S/C26H26Cl2FN3O3/c1-24(35)11-14(12-24)30-22(33)21-19(15-4-2-5-17(28)20(15)29)26(25(32-21)8-3-9-25)16-7-6-13(27)10-18(16)31-23(26)34/h2,4-7,10,14,19,21,32,35H,3,8-9,11-12H2,1H3,(H,30,33)(H,31,34)/t14-,19-,21+,24+,26-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041079 (CHEMBL3355423) Show SMILES OC[C@@H](O)CCNC(=O)[C@@H]1NC2(CCC2)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r| Show InChI InChI=1S/C25H26Cl2FN3O4/c26-13-5-6-16-18(11-13)30-23(35)25(16)19(15-3-1-4-17(27)20(15)28)21(31-24(25)8-2-9-24)22(34)29-10-7-14(33)12-32/h1,3-6,11,14,19,21,31-33H,2,7-10,12H2,(H,29,34)(H,30,35)/t14-,19-,21+,25-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041076 (CHEMBL3355419) Show SMILES Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCC2)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1 |r| Show InChI InChI=1S/C27H29Cl2FN4O3/c28-16-5-6-18-20(15-16)32-25(36)27(18)21(17-3-1-4-19(29)22(17)30)23(33-26(27)7-2-8-26)24(35)31-9-10-34-11-13-37-14-12-34/h1,3-6,15,21,23,33H,2,7-14H2,(H,31,35)(H,32,36)/t21-,23+,27-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50041024 (CHEMBL3355431) Show SMILES N[C@H]([C@@H](C1C(=O)Nc2cc(Cl)ccc12)c1cccc(Cl)c1F)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:2.15,25.27,wD:1.24,28.31,(14.74,-11.59,;13.71,-10.44,;12.2,-10.76,;11.73,-12.23,;12.64,-13.48,;14.18,-13.48,;11.73,-14.74,;10.25,-14.26,;8.92,-15.03,;7.59,-14.26,;6.25,-15.03,;7.59,-12.72,;8.92,-11.95,;10.25,-12.71,;11.17,-9.62,;11.66,-8.16,;10.63,-7.01,;9.12,-7.33,;8.65,-8.81,;7.14,-9.13,;9.68,-9.94,;9.21,-11.41,;14.18,-8.98,;13.15,-7.84,;15.69,-8.66,;16.17,-7.19,;15.13,-6.06,;15.62,-4.59,;17.13,-4.27,;17.61,-2.81,;18.15,-5.42,;17.67,-6.88,)| Show InChI InChI=1S/C23H24Cl2FN3O3/c24-11-4-9-14-17(10-11)29-22(31)19(14)18(15-2-1-3-16(25)20(15)26)21(27)23(32)28-12-5-7-13(30)8-6-12/h1-4,9-10,12-13,18-19,21,30H,5-8,27H2,(H,28,32)(H,29,31)/t12-,13-,18-,19?,21-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...				J Med Chem 57: 10486-98 (2014) Article DOI: 10.1021/jm501541j BindingDB Entry DOI: 10.7270/Q2HH6MQK
					More data for this Ligand-Target Pair

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